Allhat study protocol format

Operational Aspects of Terminating the Doxazosin Arm of ...

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Our experience in ALLHAT indicates that one cannot start planning closeout too soon, especially for a trial as large as ALLHAT. Closing out all or part of a protocol involving over 42,000 participants is a huge endeavor. With commitment, both time and financial, from …

Operational Aspects of Terminating the Doxazosin Arm of ...

Clinical trials of antihypertensives: Nature of control ...

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This paper reviews the critical issues in the control and design of antihypertension (anti-HT) clinical trials. The international guidelines and current clinical and biostatistical practices were reviewed for relevant clinical, design, end-point assessments and regulatory issues. The results are ...

Clinical trials of antihypertensives: Nature of control ...

A Randomized Trial of Intensive versus Standard Blood ...

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The most appropriate targets for systolic blood pressure to reduce cardiovascular morbidity and mortality among persons without diabetes remain uncertain. We randomly assigned 9361 persons with a ...

A Randomized Trial of Intensive versus Standard Blood ...

Post-trial follow-up data-ALLHAT Phase 3

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ALLHAT Post-Trial Follow-up Data [In PDF format] [Get Adobe Reader] Post-Trial Mortality. Post-trial deaths were identified through NDI or SSA. Causes of death (ICD-10 coding) were obtained from NDI Plus. Post-Trial Hospitalizations. Post-trial hospitalization data were available for …

Post-trial follow-up data-ALLHAT Phase 3

Operational Aspects of Terminating the Doxazosin Arm of ...

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To monitor patient safety and study Closeout of ALLHAT Doxazosin Arm 31 Figure 1 Randomized design of ALLHAT. progress, a Data and Safety Monitoring Board (DSMB) was appointed by the NHLBI. ALLHAT’s study protocol included monitoring guidelines [16]. ... a timetable was provided in a checklist format. Space was provided to enter the date of ...

Operational Aspects of Terminating the Doxazosin Arm of ...

Hypertension Control Among Newly Treated Patients Before ...

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Hypertension Control Among Newly Treated Patients Before and After Publication of the Main ALLHAT Results and JNC 7 Guidelines. Marie Krousel-Wood MD, MSPH 1, ... The BPs recorded were abstracted from medical records and were not measured as part of a study protocol. Doses for medications filled were not readily available.

Hypertension Control Among Newly Treated Patients Before ...

Do Bayesian adaptive trials offer advantages for ...

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ALLHAT incorporated several adaptive design features including conditions for early study termination and arm dropping . ALLHAT monitored each comparison with its own monitoring guideline with alpha = 0.027 according to the Dunnet procedure. Early success and …

Do Bayesian adaptive trials offer advantages for ...

Hypertension (High Blood Pressure)

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Hypertension (High Blood Pressure) FACT SHEET - Hypertension (High Blood Pressure) Updated October 2010 National Institutes of Health 1 Yesterday Hypertension is a silent killer because it has no early significant symptoms, but creates an extra load on the heart and blood vessels. The twentieth century ushered in an era of great interest

Hypertension (High Blood Pressure)

Changes in Prescribing Patterns Following Publication of ...

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PDF | On Feb 1, 2004, Peter C Austin and others published Changes in Prescribing Patterns Following Publication of the ALLHAT Trial

Changes in Prescribing Patterns Following Publication of ...

Pre-Specified Outcomes - Texas Medical Center

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Pre-Specified Outcomes ALLHAT All primary and secondary outcomes and their components were pre-specified , i.e., they appeared in the protocol, manual of operations and study forms. Primary Outcome – Coronary Heart Disease (CHD) – fatal CHD or non-fatal MI Secondary Outcomes 1. All-cause death 2.

Pre-Specified Outcomes - Texas Medical Center

Pragmatic Clinical Trials: US Payers' Views on Their Value

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5/10/2013 · Interview Format and Protocol Development ... Protocol Features The study protocol posed questions that led interviewees to explore a decision tree ... (ALLHAT) and Clinical ...

Pragmatic Clinical Trials: US Payers' Views on Their Value

A family physician questions the conclusions from ALLHAT

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A key Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) conclusion is that thiazide diuretics should be preferred for first-step antihypertensive therapy.

A family physician questions the conclusions from ALLHAT

Improving management of resistant hypertension: Rationale ...

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Improving management of resistant hypertension: Rationale and protocol for a cluster randomized trial addressing physician managers in primary care ... Based on 14,684 hypertensive patients from the ALLHAT-study, those with RH have a 1.47-fold higher risk for ... study protocol for a cluster randomized controlled trial. Trials, 16 (2015), p. 105.

Improving management of resistant hypertension: Rationale ...

Hypertension Improvement Project (HIP): study protocol and ...

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2/26/2009 · Not all medical clinics have space for study visits and group intervention sessions. The study team worked closely with clinic staff to schedule study visits on days when clinic rooms were available (e.g., provider day off) and used the waiting room (in the evenings), the clinic conference room, or a nearby facility for the group sessions.

Hypertension Improvement Project (HIP): study protocol and ...

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

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The strengths of our study include the random assignment of patients to study groups and follow-up of a large number of high-risk patients according to a common protocol, a high rate of follow-up ...

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

Hypertension Treatment Guidelines - Moser - 2004 - The ...

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In the Swedish Trial in Old Patients with hypertension-2 (STOP 2) study, AASK, the Losartan Intervention For Endpoint reduction in hypertension (LIFE), the Reduction in Endpoints in patients with Non-insulin dependent diabetes mellitus with the Angiotensin II Antagonist Losartan (RENAAL) studies, and the ALLHAT trial, there was a difference in ...

Hypertension Treatment Guidelines - Moser - 2004 - The ...

Do men and women respond differently to blood pressure ...

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10/13/2008 · For the six remaining trials, 22,43–47 we could not extract data according to criteria specified in the original study protocol. Of the 190 617 individuals, 103 268 were men and 87 349 were women (Table 1). The average proportion of women in all trials was 46.8% (range 10.9–67.2%).

Do men and women respond differently to blood pressure ...

Explore JNC 8 Hypertension Guidelines from JAMA Network

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Guidelines for Management of High Blood Pressure in Adults. In 2014, panel members of the Eighth Joint National Committee published the results of their evidence review and deliberations about the prevention, detection, evaluation, and treatment of high blood pressure.

Explore JNC 8 Hypertension Guidelines from JAMA Network

Hypertension Improvement Project (HIP): study protocol and ...

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2/26/2009 · Hypertension affects 29% of the adult U.S. population and is a leading cause of heart disease, stroke, and kidney failure. Despite numerous effective treatments, only 53% of people with hypertension are at goal blood pressure. The chronic care model suggests that blood pressure control can be achieved by improving how patients and physicians address patient self-care.

Hypertension Improvement Project (HIP): study protocol and ...

Long-Term Prognostic Value of Dobutamine Stress ...

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3/1/2012 · OBJECTIVE To determine the incremental prognostic value of dobutamine stress echocardiography (DSE) at 13-year follow-up (SD 3.2 years) for predicting mortality and cardiac events in diabetic patients. RESEARCH DESIGN AND METHODS A total of 396 diabetic patients (mean age 61 ± 11 years; 252 men [64%]) with limited exercise capacity who underwent DSE for evaluation of …

Long-Term Prognostic Value of Dobutamine Stress ...

(PDF) Doxazosin in the current treatment of hypertension ...

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In the more recent by prospectively designated overviews, which showed that ASOCIA trial, 3% of the patients suffered from adverse treatment with any commonly used regimen reduced events and 1.6% was related to the study treatment the risk of major cardiovascular events and, furthermore, format [18].

(PDF) Doxazosin in the current treatment of hypertension ...
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